You may be right about RealPlayer. However, something like that happened to me too recently without messing with Real. After an update to QT 7.1.1 my Camino browser stopped seing QT (same logo with a question mark). Reinstalling Camino after the update did the trick. Maybe you need to reinstall the browsers or at least get rid of all their preferences in your user account/library directory. Just keep the bookmarks file on the desktop and put it back after browser relaunch.
Hope this helps.
Alex
2.3 GHz DP G5, OS 10.4.6
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Alex
2.66 GHz 17" MacBook Pro, 4 GB RAM, OS 10.5.7, Office 2008, TimeWarner Cable